{"id":130,"date":"2009-10-14T13:43:52","date_gmt":"2009-10-14T20:43:52","guid":{"rendered":"http:\/\/wordpress.reed.edu\/chem201202\/2009\/10\/resolving-agents---achiral-chiral.html"},"modified":"2014-03-18T10:13:04","modified_gmt":"2014-03-18T17:13:04","slug":"resolving-agents-achiral-chiral","status":"publish","type":"post","link":"https:\/\/blogs.reed.edu\/chem201202\/2009\/10\/resolving-agents-achiral-chiral\/","title":{"rendered":"Resolving Agents &#8211; Achiral? Chiral?"},"content":{"rendered":"<p>A great question came my way right after lecture: can resolving agents by <b>achiral<\/b>?<\/p>\n<p>The short answer is no.<br \/><!--more-->To explain my &#8220;no&#8221; answer, imagine that &#8220;mint receptor protein&#8221; is achiral. In this case, R-M (the complex of R-carvone and mint receptor protein) would be the mirror image of S-M. The complexes would be enantiomers and they would have identical energies.<\/p>\n<p>This means that \u0394G would be identical for the two binding equilibria. If the enantiomers of carvone bind equally well to an &#8220;achiral&#8221; receptor, no differentiation occurs.<\/p>\n<p>So to return to the <b>Shusterman Paradox<\/b>, is the statement &#8220;raise your right hand&#8221; chiral? When it enters your brain, it leads to a different set of events than &#8220;raise your left hand&#8221;.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>A great question came my way right after lecture: can resolving agents by achiral?The short answer is no&#8230;.<\/p>\n","protected":false},"author":55,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3],"tags":[],"class_list":["post-130","post","type-post","status-publish","format-standard","hentry","category-post-lecture"],"_links":{"self":[{"href":"https:\/\/blogs.reed.edu\/chem201202\/wp-json\/wp\/v2\/posts\/130","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/blogs.reed.edu\/chem201202\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/blogs.reed.edu\/chem201202\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/blogs.reed.edu\/chem201202\/wp-json\/wp\/v2\/users\/55"}],"replies":[{"embeddable":true,"href":"https:\/\/blogs.reed.edu\/chem201202\/wp-json\/wp\/v2\/comments?post=130"}],"version-history":[{"count":2,"href":"https:\/\/blogs.reed.edu\/chem201202\/wp-json\/wp\/v2\/posts\/130\/revisions"}],"predecessor-version":[{"id":5165,"href":"https:\/\/blogs.reed.edu\/chem201202\/wp-json\/wp\/v2\/posts\/130\/revisions\/5165"}],"wp:attachment":[{"href":"https:\/\/blogs.reed.edu\/chem201202\/wp-json\/wp\/v2\/media?parent=130"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/blogs.reed.edu\/chem201202\/wp-json\/wp\/v2\/categories?post=130"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/blogs.reed.edu\/chem201202\/wp-json\/wp\/v2\/tags?post=130"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}