{"id":6112,"date":"2014-06-17T11:37:43","date_gmt":"2014-06-17T18:37:43","guid":{"rendered":"http:\/\/blogs.reed.edu\/chemistry201-202-test\/?page_id=6112"},"modified":"2025-01-17T16:19:42","modified_gmt":"2025-01-18T00:19:42","slug":"overview","status":"publish","type":"page","link":"https:\/\/blogs.reed.edu\/chemistry201-202-lab-ref-manual\/experiments\/experiment-7-grignard-synthesis-of-an-aromatic-acid\/overview\/","title":{"rendered":"Grignard Synthesis of an Aromatic Acid: Overview"},"content":{"rendered":"\n<p>Grignard reagents, RMgX, were discovered roughly a hundred years ago, yet they are still regarded as one of the most useful carbon nucleophiles. A wide range of Grignard reagents can be prepared and these reagents react with a wide range of carbon electrophiles to make new carbon-carbon bonds.<\/p>\n\n\n\n<p>In this experiment, you will attempt to generate a Grignard reagent from an unknown aryl bromide, ArBr, and then convert this reagent into an aromatic carboxylic acid, ArCO<sub>2<\/sub>H, by combining the Grignard reagent with solid CO<sub>2<\/sub> (dry ice). You will identify your unknown aryl bromide by measuring physical and spectroscopic properties of the aromatic carboxylic acid.<\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter\"><a href=\"https:\/\/blogs.reed.edu\/chemistry201-202-lab-ref-manual\/files\/2014\/06\/synthetic_plan.gif\"><img loading=\"lazy\" decoding=\"async\" width=\"499\" height=\"88\" src=\"https:\/\/blogs.reed.edu\/chemistry201-202-lab-ref-manual\/files\/2014\/06\/synthetic_plan.gif\" alt=\"synthetic plan\" class=\"wp-image-6358\" \/><\/a><\/figure><\/div>","protected":false},"excerpt":{"rendered":"<p>Grignard reagents, RMgX, were discovered roughly a hundred years ago, yet they are still regarded as one of the most useful carbon nucleophiles. A wide range of Grignard reagents can be prepared and these reagents react with a wide range of carbon electrophiles to make new carbon-carbon bonds. In this experiment, you will attempt to &hellip; <a href=\"https:\/\/blogs.reed.edu\/chemistry201-202-lab-ref-manual\/experiments\/experiment-7-grignard-synthesis-of-an-aromatic-acid\/overview\/\" class=\"more-link\">Continue reading<span class=\"screen-reader-text\"> &#8220;Grignard Synthesis of an Aromatic Acid: Overview&#8221;<\/span><\/a><\/p>\n","protected":false},"author":316,"featured_media":0,"parent":6055,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"page-experiment.php","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-6112","page","type-page","status-publish","hentry"],"acf":[],"featured_image_src":null,"_links":{"self":[{"href":"https:\/\/blogs.reed.edu\/chemistry201-202-lab-ref-manual\/wp-json\/wp\/v2\/pages\/6112","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/blogs.reed.edu\/chemistry201-202-lab-ref-manual\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/blogs.reed.edu\/chemistry201-202-lab-ref-manual\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/blogs.reed.edu\/chemistry201-202-lab-ref-manual\/wp-json\/wp\/v2\/users\/316"}],"replies":[{"embeddable":true,"href":"https:\/\/blogs.reed.edu\/chemistry201-202-lab-ref-manual\/wp-json\/wp\/v2\/comments?post=6112"}],"version-history":[{"count":13,"href":"https:\/\/blogs.reed.edu\/chemistry201-202-lab-ref-manual\/wp-json\/wp\/v2\/pages\/6112\/revisions"}],"predecessor-version":[{"id":10118,"href":"https:\/\/blogs.reed.edu\/chemistry201-202-lab-ref-manual\/wp-json\/wp\/v2\/pages\/6112\/revisions\/10118"}],"up":[{"embeddable":true,"href":"https:\/\/blogs.reed.edu\/chemistry201-202-lab-ref-manual\/wp-json\/wp\/v2\/pages\/6055"}],"wp:attachment":[{"href":"https:\/\/blogs.reed.edu\/chemistry201-202-lab-ref-manual\/wp-json\/wp\/v2\/media?parent=6112"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}